Oligonucleotide Synthesis Market Size, Share & Trends Analysis, By Product (Oligonucleotide-based drugs, Synthesized oligonucleotides,), By Application (Therapeutic applications, Research applications), By End Use (Hospitals, Pharmaceutical & biotechnology companies), By Region and Forecast Period 2022 – 2030 (Updated Version Available)

Report ID - MRC_2194 | Pages - 254 | Category - Healthcare and Pharma

Oligonucleotide Synthesis Market Overview:

Oligonucleotide synthesis Market was valued at USD 4.95 Billion in 2021 and is anticipated to grow at a CAGR of 9.5% and is expected to reach USD 11.2 Billion by 2030.

Oligonucleotide synthesis refers to the chemical process of synthesizing small, single-stranded DNA or RNA molecules, called oligonucleotides, with specific sequences. These sequences can be designed to target specific genes or regions within a genome. The process typically involves repeated cycles of chemical reactions to build up the desired oligonucleotide sequence, one nucleotide at a time. Oligonucleotides have various applications in the fields of genomics, gene therapy, and diagnostic assays, among others.

Market Dynamics:


Advancements in genetic research have been a major driver for the oligonucleotide synthesis market. Breakthroughs such as the Human Genome Project and precision medicine have increased the demand for oligonucleotides, which are used in genetic research and testing. This has led to growth in the market. Additionally, the growing investment in biotechnology has attracted more companies to the market and increased the demand for oligonucleotides, further fueling the growth of the oligonucleotide synthesis market.


The synthesis of oligonucleotides is subject to strict regulations, which can raise the cost and complexity of the process, limiting market growth. Additionally, technical difficulties during the synthesis process, such as low yields and impurities, can impact the market negatively.


The increasing use of oligonucleotides in these fields is driving the demand for these products and providing new growth opportunities. Furthermore, the development of new and innovative technologies, such as CRISPR-Cas9 and RNA interference, is also creating new opportunities for the market. As more patients seek out personalized treatment options, the demand for oligonucleotides, which are used as probes and primers in genetic testing, is expected to increase. In addition, advancements in biotechnology and genetic research are creating new applications for oligonucleotides, further expanding the market.

Covid-19 Impact

The COVID-19 pandemic has had a significant impact on the oligonucleotide synthesis market. The initial disruptions caused by lockdowns and supply chain disruptions led to a slowdown in the market’s growth. However, the increasing demand for COVID-19 testing and the development of vaccines have provided new opportunities for the oligonucleotide synthesis market. However, the ongoing uncertainty and disruptions caused by the pandemic continue to pose challenges for the market, and it is unclear what the long-term impact of COVID-19 will be on the oligonucleotide synthesis market.

Oligonucleotide synthesis Report Coverage:

Report Attributes Report Details
Study Timeline 2018-2030
Market Size in 2030 (USD Billion) 11.2 Billion
CAGR (2022-2030) 9.5%
By Product Oligonucleotide-based drugs, Synthesized oligonucleotides, Reagents, Equipment
By Application Therapeutic applications, Research applications, Diagnostic applications
By End User         Hospitals, Pharmaceutical & biotechnology companies, Diagnostic laboratories, CROs and CMOs, Academic research institutes
By Geography North America, Europe, Asia Pacific, Latin America, Middle East and Africa
Key Players Ionis Pharmaceuticals, Inc., Kaneka Corporation, Merck Kgaa, Sarepta Therapeutics, Inc., Thermo Fisher Scientific, Inc., Alnylam Pharmaceuticals, Inc., Biogen Limited, Cinven, Danaher Corporation, Eurofins Scientific

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Market Segmentation:

By Product

The pharmaceutical industry is growing with the rise of oligonucleotide-based drugs, which use RNA/DNA to target disease genes/pathways, offering advantages over traditional small molecule drugs. Synthesized oligonucleotides, short single-stranded DNA/RNA molecules, have crucial applications in genetic testing, research and drug development. Made through chemical synthesis, the quality of synthesized oligonucleotides (accuracy and purity) determines their suitability for use in PCR, sequencing, and hybridization. The quality of reagents and equipment used in the synthesis process impacts the final product’s accuracy, purity, and yield. Reagents include chemicals, enzymes, and materials, while high-quality equipment is in growing demand with the increase of oligonucleotide use in genetic testing and drug development.

By Application

The oligonucleotide synthesis market is segmented into three main applications: therapeutic, research, and diagnostic. Therapeutic applications of oligonucleotides include the use of antisense oligonucleotides, RNA interference, and aptamers for the treatment of various diseases such as cancer, genetic disorders, and cardiovascular diseases. Research applications of oligonucleotides include their use in gene expression analysis, genotyping, and epigenetic studies. Diagnostic applications of oligonucleotides include their use in disease diagnosis, pathogen detection, and personalized medicine.

By Region

North America is a significant market for consumer goods and technology products, characterized by high disposable income and well-developed infrastructure. The region is also experiencing growth in its e-commerce sector, fueled by favorable government policies and regulations. These factors contribute to the overall growth of the market in North America. Asia Pacific is a favorable destination for businesses due to its low labor costs and supportive government policies. The region is experiencing growth, driven by the rising middle-class populations and rapid urbanization, which are leading to an increased demand for consumer goods and technology products. These factors are contributing to the overall development and growth of the market in Asia Pacific.

Competitive Landscape:

The competitive landscape of the oligonucleotide synthesis market has been evaluated in the report, including the in-depth profiles of leading players in the industry. The growth of the market is driven by the increase in R&D activities, product advancements, diverse business tactics, and the launch of new applications. Some of the key players in the market include-

  • Ionis Pharmaceuticals Inc.
  • Kaneka Corporation
  • Merck Kgaa
  • Sarepta Therapeutics Inc.
  • Thermo Fisher Scientific Inc.
  • Alnylam Pharmaceuticals Inc.
  • Biogen Limited
  • Cinven
  • Danaher Corporation
  • Eurofins Scientific

Recent Development:

  • In January 2023, Thermo Fisher Scientific, a leading provider of scientific instruments and reagents, announced the acquisition of QIAGEN N.V., a global provider of sample and assay technologies, to expand its offerings in the oligonucleotide synthesis market.
  • In December 2022, Merck KGaA, a leading provider of life science solutions, announced the launch of a new line of oligonucleotide synthesis products, aimed at improving the efficiency and accuracy of the synthesis process. The new products are expected to increase the company’s market share in the oligonucleotide synthesis market.

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Oligonucleotide Synthesis Market Size, Share & Trends Analysis, By Product (Oligonucleotide-based drugs, Synthesized oligonucleotides,), By Application (Therapeutic applications, Research applications), By End Use (Hospitals, Pharmaceutical & biotechnology companies), By Region and Forecast Period 2022 – 2030 (Updated Version Available)
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